Key enzyme identified in protection of beta cells and regulation of insulin


Physiologists at the Medical College of Wisconsin have identified the enzyme thioredoxin reductase as playing a key role in protecting beta cells from oxidative stress and in the regulation of insulin secretion.

Researchers also show in this study that beta cells adapt in the absence of thioredoxin reductase by turning on alternative antioxidant pathways of protection from oxidative stress.

In addition, beta cells are very resistant to oxidative stress and use thioredoxin reductase to protect themselves from the imbalance. Oxidative stress is believed to contribute to loss of beta cell function and beta cell death in both type 1 and type 2 diabetes.

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